Endocrine Abstracts

Introduction: The demand of health care for people with gender incongruence (IG) has grown exponentially especially in young population. Due to this, there is a growing number of studies that show psychological conflicts and social functioning in those individuals who have not received gender-affirming treatment with medical intervention (pubertal block, hormone or surgical treatment) and social intervention. However, the data published so far do not represent the European cou...

Acromegaly is a complex disease with an insidious onset and diagnosis can be delayed. The aim of the study was to investigate the diagnostic delay (DD), for patients with acromegaly due to a pituitary tumour in Sweden. Data were obtained from the Swedish National Patient Register. Patients diagnosed between January 1, 2011 and December 31, 2013 in Sweden were included (n=135, 69 men, 66 women). For these patients, the occurrence of pre-defined relevant comorbidities w...

Acromegaly and comorbidities incur large costs in the Swedish health care system. The aim of the study was to describe direct costs since time of diagnosis, for patients with acromegaly due to a pituitary tumour in Sweden. Data were obtained via linkage of nationwide registers. Patients diagnosed between 1 July 2005 and 31 December 2007 in Sweden and with a follow-up of at least 6 years were included (n=105). Direct costs due to use of health care resources and pharma...

Introduction: Obesity is a multifactorial disease in whose genetic factors are involved. The integration of this factors will allow to state personalized prevention strategies, where the constant contact with the patient will have a greater success for them to follow up recommendations. Continuous technological changes allow bigger accessibility to communication, having platforms with remote control.Objective: Assessing the effectiveness of an Intelligen...

Introduction: In vitro and animal studies have suggested that changes in the secretion of ghrelin, PYY, GLP-1, GLP-2 can influence bone metabolism. An increase in osteoblastic differentiation has been observed after the administration of ghrelin and GLP-1. GLP-2 has been associated with a decrease in bone resorption and PYY inversely with markers of bone formation.Objective: To analyze the association of gastrointestinal hormones with changes in...

Introduction: Pituitary abscess (PA) is a rare condition, representing less than 1% of pituitary lessions. Only around 200 cases have been reported in the scientific literature. Preoperative diagnosis is often challenging due to nonspecific clinical and radiological manifestations.Materials and methods: Retrospective descriptive cohort study. We analyze demographic and clinical variables, hormonal involvement, recurrence, type of surgery and antibiotic t...

Methods: Descriptive retrospective study among patients who underwent ETPS for ACTH-secreting pituitary adenomas performed by the same surgical team from January/2013 to January/2017.Results: 27 ACTH-secreting pituitary adenomas operated via ETPS. 20 (74.1%) were women, median age at surgery was 43.25 [29.65–61.59] years and median follow-up was 3.13 [1.6–6.69] years. Presurgically, 25 (92.59%) patients recieved drugs for control cortisol hyper...

Methods: We conducted a retrospective descriptive study including 67 patients with non-functioning pituitary adenomas surgicaly removed via ETPS beetwen January/2013 to January/2017.Results: Among 67 patients with non-functioning pituitary adenomas surgicaly removed via ETPS 44 (65.67%) were men. 52 (77.61%) patients recieved their first surgery, 14 (20.9%) had been operated one time before and 1 (1.49%) had been operated two times. Every patient reopera...

Introduction: Cross sex hormonal therapy with testosterone is used in female-to-male transgender people to induce the desired secondary sexual features; this could lead to an increased risk of cardiovascular diseases. Data published on this subject is scarce and contradictory.Objective: To evaluate effects on weight, inflammatory and prothrombotic parameters, lipid profile, and insulin resistance after 3–4 months of testosterone treatment in transse...

The thyroid gland functions in supplying thyroid hormones (TH) to the body periphery, which is enabled by cathepsin-mediated thyroglobulin proteolysis and TH translocation across membranes by the Mct8, Mct10, and Lat2 transporters. Previously, we showed that cathepsin K-deficient mice feature normal thyroid phenotypes which is, in part, due to the functional compensation through cathepsin L upregulation that is independent of the classical hypothalamus–pituitary–thyr...